Apo E4 and lipoprotein-associated phospholipase A2 synergistically increase cardiovascular risk
نویسندگان
چکیده
منابع مشابه
Lipoprotein-Associated Phospholipase A2, Vascular Inflammation and Cardiovascular Risk Prediction
Circulating lipoprotein-associated phospholipase A2 (Lp-PLA2) is a marker of inflammation that plays a critical role in atherogenesis; its inhibition may have antiatherogenic effects. Studies from the West of Scotland Coronary Prevention Study (WOSCOPS), Monitoring Trends and Determinants in Cardiovascular Diseases (MONICA) and Rotterdam cohorts have shown that Lp-PLA2 is an independent predict...
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I. Description Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase, is an enzyme that hydrolyzes phospholipids and is primarily associated with low-density lipoproteins (LDLs). Accumulating evidence has suggested that Lp-PLA2 is a biomarker of coronary artery disease (CAD) and may have a proinflammatory role in the progression of atheroscl...
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ژورنال
عنوان ژورنال: Atherosclerosis
سال: 2012
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2012.04.021